Privitera M ,. Frank Gilliam Search articles by 'Frank Gilliam'. Gilliam F. Affiliations 1 author 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract Epilepsy often requires life-long treatment with antiepileptic drugs AEDs.
For clinicians to meet the challenges of patient management, data on AED performance based on clearly defined and consistently applied outcome measures are needed.
Ideally, the design of AED clinical trials should be relevant to real-world settings, providing reliable, valid, and comprehensive information on efficacy, tolerability, and quality of life QOL. Each provides important information about a drug's performance. Here we define and review endpoints for measuring AED treatment success and explore the concepts of efficacy, tolerability, QOL, retention, and compliance as well as their usefulness as clinical trial endpoints. Full text links Read article at publisher's site DOI : Smart citations by scite.
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Active control trials: endpoints beyond conventional efficacy and tolerability measures. Quality of life in seizure-free patients with epilepsy on monotherapy. Funding Funders who supported this work. Joining Europe PMC.
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Spontaneous reports of symptoms or use of specific checklists have advantages and disadvantages. Studies aimed at ensuring greater standardization in safety assessment should be encouraged, especially with respect to need of obtaining quantitative estimates, and information on both prevalence and incidence of side effects should be reported in all trials.
Abstract This article provides a comprehensive discussion of clinical outcome measures used in trials aimed at assessing the efficacy and safety of antiepileptic drugs. Publication types Review. Substances Anticonvulsants.
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